Catalytic Asymmetric Synthesis of N‐Chiral Amine Oxides |
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| Authors: | Dr Sukalyan Bhadra Prof?Dr Hisashi Yamamoto |
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| Affiliation: | 1. Molecular Catalyst Research Center, Chubu University, Aichi, Japan;2. Inorganic Materials and Catalysis Division, CSIR-Central Salt and Marine Chemicals Research Institute, Gujarat, India |
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| Abstract: | Direct asymmetric synthesis of N‐chiral amine oxides was accomplished (up to 91:9 e.r.) by means of a bimetallic titanium catalyst. A hydroxy group situated at the γ‐position of the N stereocenter enables the desired N‐oxidation through dynamic kinetic resolution of the trivalent amine substrates. The method was further extended to the kinetic resolution of racemic γ‐amino alcohols with a preexisting stereocenter, giving an important class of enantioenriched (up to 99.9:0.1 e.r.) building blocks that are otherwise difficult to synthesize. |
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| Keywords: | asymmetric catalysis dynamic kinetic resolution homogeneous catalysis nitrogen oxides titanium |
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