A Platinum(II) Complex of Heptamethine Cyanine for Photoenhanced Cytotoxicity and Cellular Imaging in Near‐IR Light |
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| Authors: | Dr Koushambi Mitra Charles E Lyons ProfDr Matthew C T Hartman |
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| Affiliation: | 1. Department of Chemistry, Virginia Commonwealth University, Richmond, VA, USA;2. Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA |
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| Abstract: | Controlled generation of cytotoxic agents with near‐IR light is a current focus of photoactivated cancer therapy, including that involving cytotoxic platinum species. A heptamethine cyanine scaffolded PtII complex, IR797‐Platin exhibits unprecedented Pt?O bond scission and enhancement in DNA platination in near‐IR light. This complex also displayed significant singlet oxygen quantum yield thereby qualifying as a near‐IR photodynamic therapeutic agent. The complex showed 30–60 fold enhancement of cytotoxicity in near‐IR light in various cancer cell lines. The cellular imaging properties were also leveraged to observe its significant co‐localization in cytoplasmic organelles. This is the first demonstration of a near‐IR light‐initiated therapy involving the cytotoxic effects of both active cisplatin and singlet oxygen. |
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| Keywords: | cancer cyanines imaging agents photodynamic therapy platinum |
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