Copper‐Catalyzed Stereoselective Aminoboration of Bicyclic Alkenes |
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| Authors: | Ryosuke Sakae Dr Koji Hirano Prof?Dr Tetsuya Satoh Prof?Dr Masahiro Miura |
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| Affiliation: | Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565‐0871 (Japan) |
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| Abstract: | A copper‐catalyzed aminoboration of bicyclic alkenes, including oxa‐ and azabenzonorbornadienes, has been developed. With this method, amine and boron moieties are simultaneously introduced at an olefin with exo selectivity. Subsequent stereospecific transformations of the boryl group can provide oxygen‐ and nitrogen‐rich cyclic molecules with motifs that may be found in natural products or pharmaceutically active compounds. Moreover, a catalytic asymmetric variant of this transformation was realized by using a copper complex with a chiral bisphosphine ligand, namely (R,R)‐Ph‐BPE. |
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| Keywords: | alkenes aminoboration copper synthetic methods umpolung |
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