Processes To Separate Enantiomers |
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| Authors: | Prof Heike Lorenz Prof Andreas Seidel‐Morgenstern |
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| Affiliation: | 1. Max‐Planck‐Institut für Dynamik komplexer technischer Systeme, Sandtorstrasse 1, 39106 Magdeburg (Germany);2. Otto‐von‐Guericke‐Universit?t Magdeburg, Institut für Verfahrenstechnik, Universit?tsplatz 2, 39106 Magdeburg (Germany) |
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| Abstract: | The provision of pure enantiomers is of increasing importance not only for the pharmaceutical industry but also for agrochemistry and biotechnology. In general, there are two rival approaches to provide pure enantiomers. The “chiral” approach is based on developing an asymmetric synthesis of just one of the enantiomers, while the “racemic” approach is based on separating mixtures of the two enantiomers. In the last few years remarkable progress has been achieved in the latter area. This Review focuses in particular on enantioselective crystallization processes and preparative chromatography, including hybrid processes and the incorporation of racemization steps. Several examples from our research are used for illustration purposes. |
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| Keywords: | crystallization enantiomers chromatography hybrid processes phase diagrams racemization separation methods |
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