Formation of C(sp2)Boronate Esters by Borylative Cyclization of Alkynes Using BCl3 |
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| Authors: | Andrew J Warner James R Lawson Valerio Fasano Dr Michael J Ingleson |
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| Affiliation: | School of Chemistry, University of Manchester, Manchester, M13 9PL (UK) |
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| Abstract: | BCl3 is an inexpensive electrophile which induces the borylative cyclization of a wide range of substituted alkynes to regioselectively form polycycles containing synthetically versatile C(sp2)? boronate esters. It proceeds rapidly, with good yields and is compatible with a range of functional groups and substitution patterns. Intermolecular 1,2‐carboboration of alkynes is also achieved using BCl3 to generate trisubstituted vinyl boronate esters. |
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| Keywords: | alkynes boron cyclizations heterocycles synthetic methods |
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