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Combining Organocatalysis with Central‐to‐Axial Chirality Conversion: Atroposelective Hantzsch‐Type Synthesis of 4‐Arylpyridines |
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| Authors: | Ophélie Quinonero Marion Jean Dr Nicolas Vanthuyne Prof?Dr Christian Roussel Dr Damien Bonne Prof?Dr Thierry Constantieux ProfDr Cyril Bressy Dr Xavier Bugaut Prof?Dr Jean Rodriguez |
| Affiliation: | Aix Marseille Université, Centrale Marseille, CNRS, iSm2 UMR 7313, Marseille, France |
| Abstract: | Suitably substituted enantioenriched 4‐aryl‐1,4‐dihydro‐pyridines prepared by an organocatalytic enantioselective Michael addition were oxidized with MnO2 into axially chiral 4‐arylpyridines with central‐to‐axial chirality conversion. Moderate to complete percentages (cp) were observed, and a model for the conversion of chirality is discussed. |
| Keywords: | atropisomers chiral conversion enantioselectivity organocatalysis pyridines |
