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Total Synthesis of (+)‐Rubriflordilactone A |
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| Authors: | Shermin S Goh Guilhem Chaubet Birgit Gockel Marie‐Caroline A Cordonnier Hannah Baars Andrew W Phillips Edward A Anderson |
| Abstract: | Two enantioselective total syntheses of the nortriterpenoid natural product rubriflordilactone A are described, which use palladium‐ or cobalt‐catalyzed cyclizations to form the CDE rings, and converge on a late‐stage synthetic intermediate. These key processes are set up through the convergent coupling of a common diyne component with appropriate AB‐ring aldehydes, a strategy that sets the stage for the synthetic exploration of other members of this family of natural products. |
| Keywords: | cyclotrimerization domino reactions natural products total synthesis transition metal catalysis |
