Immuno‐Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents |
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Authors: | Daniel Yuan Qiang Wong Charmian Hui Fang Yeo Prof Wee Han Ang |
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Affiliation: | Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore (Singapore) |
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Abstract: | There is growing consensus that the clinical therapeutic efficacy of some chemotherapeutic agents depends on their off‐target immune‐modulating effects. Pt anticancer drugs have previously been identified to be potent immunomodulators of both the innate and the adaptive immune system. Nevertheless, there has been little development in the rational design of Pt‐based chemotherapeutic agents to exploit their immune‐activating capabilities. The FPR1/2 formyl peptide receptors are highly expressed in immune cells, as well as in many metastatic cancers. Herein, we report a rationally designed multimodal PtIV prodrug containing a FPR1/2‐targeting peptide that combines chemotherapy with immunotherapy to achieve therapeutic synergy and demonstrate the feasibility of this approach. |
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Keywords: | antitumor agents cisplatin drug targeting peptides platinum |
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