Real‐Time In Vivo Quantitative Monitoring of Drug Release by Dual‐Mode Magnetic Resonance and Upconverted Luminescence Imaging |
| |
| Authors: | Dr Jianan Liu Dr Jiwen Bu Prof Wenbo Bu Dr Shengjian Zhang Dr Limin Pan Dr Wenpei Fan Dr Feng Chen Prof Liangpin Zhou Prof Weijun Peng Prof Kuaile Zhao Prof Jiulin Du Prof Jianlin Shi |
| |
| Affiliation: | 1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding‐xi Road, Shanghai 200050 (China);2. Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue‐Yang Road, Shanghai 200031 (China);3. Department of Radiology, Fudan University Cancer Hospital, Fudan University, Shanghai 200032 (China) |
| |
| Abstract: | Insufficient or excess drug doses, due to unknown actual drug concentrations at the focus, are one of the main causes of chemotherapy failure for cancers. In this regard, the real‐time monitoring of the release of anticancer drugs from nanoparticle drug delivery systems is of crucial importance, but it remains a critical and unsolved challenge. Herein, we report the proposal and development of a novel concept of real‐time monitoring of NIR‐triggered drug release in vitro and in vivo by using simultaneous upconverted luminescence (UCL) and magnetic resonance (MR) imaging. Such a monitoring strategy features the high sensitivity of UCL and the high‐resolution, noninvasiveness, and tissue‐depth‐independence of MR imaging. The dual‐mode real‐time and quantitative monitoring of drug release can be applied to determine online the drug concentrations in vivo in the tissue regions of interest and, therefore, to avoid insufficient or excess drug dosings. |
| |
| Keywords: | drug delivery imaging LRET nanoparticles sensing |
|
|
