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Base‐Controlled Selectivity in the Synthesis of Linear and Angular Fused Quinazolinones by a Palladium‐Catalyzed Carbonylation/Nucleophilic Aromatic Substitution Sequence |
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| Authors: | Jianbin Chen Dr Kishore Natte Dr Anke Spannenberg Dr Helfried Neumann Prof?Dr Peter Langer Prof?Dr Matthias Beller Prof?Dr Xiao‐Feng Wu |
| Affiliation: | Leibniz‐Institut für Katalyse an der Universit?t Rostock e.V. Albert‐Einstein‐Strasse 29a, 18059 Rostock (Germany) |
| Abstract: | A new approach for the facile synthesis of fused quinazolinone scaffolds through a palladium‐catalyzed carbonylative coupling followed by an intramolecular nucleophilic aromatic substitution is described. The base serves as the key modulator: Whereas DBU gives rise to the linear isomers, Et3N promotes the preferential formation of angular products. Interestingly, a light‐induced 4+4 reaction of the product was also observed. |
| Keywords: | carbonylation domino reactions nucleophilic aromatic substitution palladium catalysts quinazolinones |
