Synthesis of Pyrimidine,Dihydropyrimidinone, and Dihydroimidazole Derivatives under Free Solvent Conditions and Their Antibacterial Evaluation |
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| Authors: | Ahmed M Soliman Shaaban K Mohamed Mahmoud Abd El Aleem Ali Ali El‐Remaily H Abdel‐Ghany |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Sohag University, Sohag, Egypt;2. School of Chemistry and Environmental Science, Manchester Metropolitan University, Manchester, United Kingdom |
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| Abstract: | The biologically active compounds of pyrimidine, dihydropyrimidinone, and dihydroimidazole have been synthesized in excellent yield under free solvent conditions. The antibacterial evaluation of the products showed a high inhibitory effect. Reaction of 2‐guanidinobenzothiazole with several active methylene compounds has revealed formation of the corresponding pyrimidine, dihydropyrimidinone, and dihydroimidazole derivatives under free solvent conditions in very good yield. All compounds have been characterized on the basis of IR, 1H NMR, 13C NMR, mass spectrometry, and X‐ray. |
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