A Mild and Efficient Synthesis of Novel Isoxazolyl‐Benzo[d]Pyrazino[2,1‐b] [1,3]Oxazoles |
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| Authors: | Eligeti Rajanarendar Paka Venkateshwarlu Saini Ramakrishna Dharavath Nagaraju |
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| Affiliation: | Department of Chemistry, Kakatiya University, Warangal, AP, India |
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| Abstract: | Synthesis of novel 2‐3‐methyl‐5‐(E)‐2‐aryl‐1‐ethenyl]‐4‐isoxazolyl‐4,10a‐diaryl‐1,10a‐dihydro‐2H‐benzod]pyrazino2,1‐b]1,3]oxazoles 5 were simply achieved by the reaction of 2‐3‐methyl‐5‐(E)‐2‐aryl‐1‐ethenyl]‐4‐isoxazolyl(2‐oxo‐2‐arylethyl)amino]‐1‐aryl‐1‐ethanones 3 with o‐aminophenol 4 in the presence of CAN catalyst. The intermediates, 2‐3‐methyl‐5‐(E)‐2‐aryl‐1‐ethenyl]‐4‐isoxazolyl(2‐oxo‐2‐arylethyl)amino]‐1‐aryl‐1‐ethanones 3 , were prepared by the reaction of 4‐amino‐3‐methyl‐5‐styrylisoxazole 1 , with phenacylbromides 2 in ethanol in the presence of K2CO3. The structures of the newly synthesized compounds 3a , 3b , 3c , 3d , 3e , 3f , 3g , 3h , 3i , 3j , 3k , 3l and 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i , 5j , 5k , 5l have been confirmed by analytical and spectral data. |
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