| 增溶性辅料泊洛沙姆188与胆酸聚集形态的介观模拟 |
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| 引用本文： | 刘南岑,史新元,乔延江.增溶性辅料泊洛沙姆188与胆酸聚集形态的介观模拟[J].中国科学:化学,2011(3):500-508. |
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| 作者姓名： | 刘南岑 史新元 乔延江 |
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| 作者单位： | 首都医科大学中医药学院;北京中医药大学中药信息工程研究中心; |
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| 基金项目： | 国家中医药管理局中医药行业科研专项(200708006)资助 |
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| 摘 要： | 为了建立符合中药特点的增溶性药用辅料的筛选与评价方法,本研究以清开灵注射液为研究载体,采用介观动力学方法(MesoDyn)研究其难溶活性成分胆酸与增溶性辅料泊洛沙姆188之间的相互作用,探讨了胆酸对泊洛沙姆188临界胶束浓度的影响及泊洛沙姆188浓度、模拟时间、温度对两者聚集体构型的影响,并采用实验方法验证了部分模拟结果,为中药注射剂增溶性辅料的科学应用提供一定基础.结果表明:在清开灵注射液中活性成分胆酸的存在下,泊洛沙姆188的临界胶束浓度范围为0.6%～0.7%,降低了泊洛沙姆188自身的临界胶束浓度,为使清开灵注射液中的胆酸(3%)全部增溶,泊洛沙姆188浓度应为1.7%.
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| 关 键 词： | 泊洛沙姆188 胆酸 增溶 介观模拟 聚集体 |
Mesoscopic simulation study on the aggregation behavior of poloxamer 188 and cholalic acid |
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| LIU NanCen,SHI XinYuan & QIAO YanJiang Capital Medical University,Beijing ,China Research Center of TCM-information Engineering,Beijing University of Chinese Medicine,Beijing ,China.Mesoscopic simulation study on the aggregation behavior of poloxamer 188 and cholalic acid[J].Scientia Sinica Chimica,2011(3):500-508. |
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| Authors: | LIU NanCen SHI XinYuan & QIAO YanJiang Capital Medical University Beijing China Research Center of TCM-information Engineering Beijing University of Chinese Medicine Beijing China |
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| Affiliation: | LIU NanCen1,SHI XinYuan2 & QIAO YanJiang2 1 Capital Medical University,Beijing 100069,China 2 Research Center of TCM-information Engineering,Beijing University of Chinese Medicine,Beijing 100102,China |
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| Abstract: | To establish the screening and evaluation methods and provide some basis for experimental study on solubilization accessories of the Traditional Chinese Medicine Injection. Qingkailing Injection has been taken as an example to explore the interaction between active ingredient and the solubilization accessories, poloxamer 188. The critical micelle concentration of poloxamer 188 in cholalic acid(active ingredient)environment has been studied using Mesoscopic Dynamics (MesoDyn). Concentration, simulation time ... |
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| Keywords: | poloxamer 188 cholalic acid solubilization accessories mesoscopic simulation aggregation |
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