Nickel‐Promoted Highly Regioselective Carboxylation of Aryl Ynol Ether and Its Application to the Synthesis of Chiral β‐Aryloxypropionic Acid Derivatives |
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| Authors: | Dr Nozomi Saito Zhongdong Sun Prof Dr Yoshihiro Sato |
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| Affiliation: | 1. Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060‐0812 (Japan);2. ACT‐C (Japan) Science and Technology Agency (JST), Sapporo 060‐0812 (Japan) |
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| Abstract: | Nickel(0)‐promoted carboxylation of aryl ynol ether proceeded in a highly regioselective manner to produce α‐substituted‐β‐aryloxyacrylic acid derivatives. The α‐substituted‐β‐aryloxyacrylic acids were transformed into the corresponding β‐aryloxypropionic acid derivative as an optically active form via rhodium‐catalyzed asymmetric hydrogenation. |
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| Keywords: | asymmetric catalysis carbon dioxide nickel rhodium ynol ether |
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