Topotecan‐Loaded Mesoporous Silica Nanoparticles for Reversing Multi‐Drug Resistance by Synergetic Chemoradiotherapy |
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| Authors: | Dr Bo Shen Dr Kuaile Zhao Dr Shulan Ma Dr Dexiao Yuan Dr Yang Bai |
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| Affiliation: | 1. Institute of Radiation Medicine, Fudan University, Shanghai 200032 (China);2. Department of Radiation Oncology, Shanghai Cancer Hospital, Fudan University, Shanghai 200032 (China);3. Training Centre of Medical Experiments, Basic Medical School, Fudan University, Shanghai 200032 (China) |
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| Abstract: | Multi‐drug resistance (MDR) has become a major challenge for the further improvement of chemotherapy. Thus, more effective strategies for further enhancing the treatment against cancer by overcoming MDR are warranted. In this study, by the encapsulation of the radiosensitizing drug TPT into mesoporous silica nanoparticles (MSNs), the combined use of drug‐delivered chemotherapy and high‐energy X‐ray induced radiotherapy could produce synergetic chemoradiotherapeutic effects to kill multi‐drug resistant cells through significant DNA damage, thus leading to an efficient circumvention of MDR. We hope that this synergetic dual‐mode treatment strategy may achieve higher oncolytic efficacy and find use in future clinical anti‐MDR applications. |
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| Keywords: | cancer chemoradiotherapy DNA damage mesoporous materials multi‐drug resistance radiosensitization |
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