Surface‐Bound Cucurbit[8]uril Catenanes on Magnetic Nanoparticles Exhibiting Molecular Recognition |
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| Authors: | Xiaohe Ren Yuchao Wu Dr David E Clarke Dr Ji Liu Dr Guanglu Wu Prof Oren A Scherman |
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| Affiliation: | Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, UK), Fax: (+44)?01223-334866 |
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| Abstract: | We demonstrate the preparation of surface‐bound cucurbit8]uril (CB8]) catenanes on silica nanoparticles (NPs), where CB8] was employed as a tethered supramolecular “handcuff” to selectively capture target guest molecules. In this catenane, CB8] was threaded onto a methyl viologen (MV2+) axle and immobilized onto silica NPs. The formation of CB8] catenanes on NPs were confirmed by UV/Vis titration experiments and lithographic characterization, demonstrating a high density of CB8] on the silica NPs surface, 0.56 nm?2. This CB8] catenane system exhibits specific molecular recognition towards certain aromatic molecules such as perylene bis(diimide), naphthol and aromatic amino acids, and thus it can act as a nanoscale molecular receptor for target guests. Furthermore, we also demonstrate its use as an efficient and recyclable nano‐platform for peptide separation. By embedding magnetic NPs inside silica NPs, separation could be achieved by simply applying an external magnetic field. Moreover, the peptides captured by the catenanes could be released by reversible single‐electron reduction of MV2+. The entire process demonstrated high recoverability. |
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| Keywords: | catenanes cucurbit[n]urils host– guest systems molecular recognition nanoparticles |
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