ESI‐MS studies of the non‐covalent interactions between biologically important metal ions and N‐sulfonylcytosine derivatives |
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| Authors: | Valentina Klju?ari? Renata Kobeti? Jasmina Rinkovec Snje?ana Kazazi? Dubravka Gembarovski Dijana Safti? Josipa Mati? ?eljka Ban Biserka ?ini? |
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| Affiliation: | 1. Ministry of Defense of the Republic of Croatia, “Dr. Franjo Tu?man” Croatian Defense Academy, Zagreb, Croatia;2. Laboratory for Biomolecular Interactions and Spectroscopy, Division of Organic Chemistry and Biochemistry, Ru?er Bo?kovi? Institute, Zagreb, Croatia;3. Institute for Medical Research and Occupational Health, Zagreb, Croatia;4. Laboratory for Chemical Kinetics and Atmospheric Chemistry, Division of Physical Chemistry, Ru?er Bo?kovi? Institute, Zagreb, Croatia;5. Fidelta d.o.o., Zagreb, Croatia |
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| Abstract: | The aim of this report is to present the electrospray ionization mass spectrometry results of the non‐covalent interaction of two biologically active ligands, N‐1 ‐ (p‐toluenesulfonyl)cytosine, 1‐TsC, 1 and N‐1 ‐ methanesulfonylcytosine, 1‐MsC, 2 and their Cu(II) complexes Cu(1‐TsC‐N3)2Cl2, 3 and Cu(1‐MsC‐N3)2Cl2 and 4 with biologically important cations: Na+, K+, Ca2+, Mg2+ and Zn2+. The formation of various complex metal ions was observed. The alkali metals Na+ and K+ formed clusters because of electrostatic interactions. Ca2+ and Mg2+ salts produced the tris ligand and mixed ligand complexes. The interaction of Zn2+ with 1–4 produced monometal and dimetal Zn2+ complexes as a result of the affinity of Zn2+ ions toward both O and N atoms. Copyright © 2016 John Wiley & Sons, Ltd. |
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| Keywords: | N‐1‐sulfonylcytosine derivatives Cu(II) complexes metal ions Na+ K+ Ca2+ Mg2+ and Zn2+ non‐covalent interactions ESI‐MS |
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