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| 二茂铁席夫碱的合成及细胞毒活性 | |
| 引用本文： | 谭平,喻爱和,闫静,弭永生,李珺姊,向建南.二茂铁席夫碱的合成及细胞毒活性[J].高等学校化学学报,2011,32(5):1083-1087. |
| 作者姓名： | 谭平 喻爱和 闫静 弭永生 李珺姊 向建南 |
| 作者单位： | 1. 湖南机电职业技术学院,长沙,410151 2. 湖南大学化学化工学院,长沙,410082 3. 湖南大学生物医学工程中心,长沙,4100824 4. 湖南大学化学化工学院,长沙 410082;湖南大学生物医学工程中心,长沙,4100824;湖南大学化学生物传感与计量学国家重点实验室,长沙,410082 |
| 摘 要： | 为了研究二茂铁席夫碱对癌细胞毒性，以二茂铁甲醛或乙酰基二茂铁与3-取代-4-氨基-1,2,4-三唑-5-硫酮或酰肼缩合，得到6个新型的含二茂铁基的缩胺类席夫碱和4个酰腙类席夫碱.利用1H NMR，IR,MS谱和元素分析对化合物结构进行了表征.体外细胞测试结果表明，所有化合物对Hela (宫颈癌细胞)均有一定的抑制生长活性，而且杂环缩胺类席夫碱2的细胞毒活性要强于酰腙类席夫碱4. |
| 关 键 词： | 二茂铁甲醛 三唑 酰肼 席夫碱 细胞毒活性 |
| 收稿时间： | 2010-07-13 |
Synthesis and Cytotoxic Activities of Ferrocene Schiff Bases |
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| TAN Ping,YU Ai-He,YAN Jing,MI Yong-Sheng,LI Jun-Zi,XIANG Jian-Nan.Synthesis and Cytotoxic Activities of Ferrocene Schiff Bases[J].Chemical Research In Chinese Universities,2011,32(5):1083-1087. | |
| Authors: | TAN Ping YU Ai-He YAN Jing MI Yong-Sheng LI Jun-Zi XIANG Jian-Nan |
| Affiliation: | 1. Department of Biologic and Chemical Engineering, Hunan Mechanical and Electrical Polytechnic College, Changsha 410151, China; 2. College of Chemistry and Chemical Engineering, 3. Bio-medicine Engineering Center, 4. State Key Laboratory of Chem/Biosensing and Chemometrics, Hunan University, Changsha 410082, China |
| Abstract: | Ferrocene derives have many special properties. In order to evaluate cytotoxic activity of ferrocene Schiff base, six novel ferrocene Schiff bases were synthesized through the reaction of ferrocene carboxaldehyde with 3-substituted-4-amino-1,2,4-triazole-5-thione and four new ferrocene acylhydrazone Schiff bases were also synthesized with ferrocenecarboxaldehyde or acetylferrocene with acylhydrazine. Its structure were characterized by 1H NMR，IR , MS and Element analysis. their cytotoxic activities were determined in vitro by an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using human cervical cancer cells (Hela). The results indicated that these compounds exhibited some cytotoxic activities against cancer cells. The mechanism of this useful property of these compounds should be conformed in the future. |
| Keywords: | Ferrocenecarboxaldehyde Triazole Acylhydrazine Schiffbase Cytotoxicactivity |
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