Novel 1,2,3,4‐Tetrahydroquinazolinones via Reaction of 2‐Amino‐N‐substituted Benzamides and Dimethyl Acetylenedicarboxylate |
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| Authors: | Semiramis Nahavandian Sadegh Allameh Mina Saeedi Shirin Ansari Mohammad Mahdavi Alireza Foroumadi Abbas Shafiee |
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| Affiliation: | 1. Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran;2. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran;4. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran, (phone: +98‐21‐66406757;5. fax: +98‐21‐66461178) |
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| Abstract: | Reaction of 2‐amino‐N‐substituted benzamides and dimethyl acetylenedicarboxylate (DMAD) in the presence of 1,8‐diazabicyclo5.4.0]undec‐7‐ene (DBU) in H2O at room temperature led to the formation of novel 1,2,3,4‐tetrahydroquinazolinones. |
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| Keywords: | Quinazolinones Benzamides Acetylenedicarboxylate dimethyl (DMAD) Water‐mediated reaction |
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