An Efficient Stereoselective Total Synthesis of Bioactive (3R,5R)‐1‐(4‐Hydroxyphenyl)‐7‐phenylheptane‐3,5‐diol via Asymmetric Aldol Reaction |
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| Authors: | Perla Ramesh Atla Raju Nitin W Fadnavis |
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| Affiliation: | 1. Natural Products Chemistry Division, CSIR‐Indian Institute of Chemical Technology, Tarnaka, Hyderabad‐500007, India, (phone: +91‐40‐27191631;2. fax: +91‐40‐27160512) |
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| Abstract: | An efficient stereoselective total synthesis of (3R,5R)‐1‐(4‐hydroxyphenyl)‐7‐phenylheptane‐3,5‐diol ( 1 ) is reported based on the Mukaiyama aldol reaction. The total synthesis of compound 1 was accomplished with 30% overall yield in simple eight steps from commercially available trans‐cinnamaldehyde. |
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| Keywords: | (3R 5R)‐1‐(4‐Hydroxyphenyl)‐7‐phenylheptane‐3 5‐diol Stereoselective synthesis Mukaiyama aldol reaction |
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