Synthesis of 4‐Aryl‐8‐fluoro‐3a,4,5,9b‐tetrahydro‐3H‐cyclopenta[c]quinolines and Their Ozonides |
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| Authors: | Alexander G Tolstikov Rimma G Savchenko Elena S Lukina Denis V Nedopekin Regina M Limantceva Leonard M Khalilov Ekaterina S Mescheryakova Victor N Odinokov |
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| Affiliation: | Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, pr. Oktyabrya, 141, RU‐450075 Ufa (fax: +7?347?284?2750) |
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| Abstract: | 4‐Aryl‐8‐fluoro‐3a,4,5,9b‐tetrahydro‐3H‐cyclopentac]quinolines are synthesized by acid‐catalyzed (CF3CO2H) three‐component cyclocondensation of 4‐fluoroaniline with aromatic aldehydes and cyclopentadiene. Stable ozonides with (1R*,4S*,5aR*,6S*,11bS*)‐configurations are obtained by ozonolysis of corresponding trifluoroacetyl derivatives. |
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| Keywords: | Aniline 4‐fluoro‐ Quinoline 3a 4 5 9b‐tetrahydro‐ Cyclocondensation Ozonolysis |
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