Palmarumycins from the Endophytic Fungus Lasiodiplodia pseudotheobromae XSZ‐3 |
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| Authors: | Xiaojing Lü Gang Chen Zhanlin Li Yuhong Zhang Zaiying Wang Weiwei Rong Yuehu Pei Huaqi Pan Huiming Hua Jiao Bai |
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| Affiliation: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, P.?R. China (phone: +86‐24‐23986465);2. Key Laboratory of Structure‐Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, P.?R. China;3. Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, P.?R. China |
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| Abstract: | One new and three known spiro‐dioxynaphthalene compounds, related to palmarumycins, were isolated from the extracts of fungus Lasiodiplodia pseudotheobromae XSZ‐3. Their structures were established by spectroscopic methods (1D‐ and 2D‐NMR, HR‐ESI‐MS, etc.). The absolute configuration of 1 was determined by comparison of quantum‐chemical TDDFT (time‐dependent density‐functional theory) calculated and experimental ECD (electronic circular dichroism) spectra. The cytotoxic activities of 1 – 4 against HL‐60 cell line were evaluated by trypan blue‐staining assay. |
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| Keywords: | Lasiodiplodia pseudotheobromae Endophytic fungus Fungi Palmarumycins Cytotoxic activity |
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