Polyhydroxylated Sterols from the South China Sea Gorgonian Verrucella umbraculum |
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| Authors: | Fei Cao Chang‐Lun Shao Yu Wang Kai‐Xia Xu Xin Qi Chang‐Yun Wang |
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| Affiliation: | Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.?R. China, (phone/fax: +86‐532‐82031536, ext. 266003) |
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| Abstract: | Two new polyhydroxylated sterols, named verumbsteroids A and B ( 1 and 2 , resp.), along with seven known analog, 3 – 9 , were isolated from the gorgonian Verrucella umbraculum collected from the South China Sea. The structures and relative configurations of the new compounds were elucidated by comprehensive spectroscopic investigations. The absolute configuration of 1 was determined by using modified Mosher method with the acetonide derivative of 1 . Compounds 1 and 3 – 5 were found to show cytotoxicities against five human tumor cell lines (HL‐60, K562, HeLa, A‐549, and HCT‐116) with the IC50 values ranging from 2.76 to 9.62 μM . |
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| Keywords: | Verrucella umbraculum Verumbsteroids A and B Gorgonian Sterols Cytotoxic activity |
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