|
|||||
|
|
Tumour‐Targeted Drug Delivery with Mannose‐Functionalized Nanoparticles Self‐Assembled from Amphiphilic β‐Cyclodextrins |
|
| Authors: | Zhou Ye Dr Quan Zhang Shengtao Wang Priya Bharate Silvia Varela‐Aramburu Prof Mengji Lu Prof Peter H Seeberger Prof Jian Yin |
| Affiliation: | 1. Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, P. R. China;2. Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany;3. Institute of Virology, University Hospital Essen, Essen, Germany |
| Abstract: | Multivalent mannose‐functionalized nanoparticles self‐assembled from amphiphilic β‐cyclodextrins (β‐CDs) facilitate the targeted delivery of anticancer drugs to specific cancer cells. Doxorubicin (DOX)‐loaded nanoparticles equipped with multivalent mannose target units were efficiently taken up via receptor‐mediated endocytosis by MDA‐MB‐231 breast cancer cells that overexpress the mannose receptor. Upon entering the cell, the intracellular pH causes the release of DOX, which triggers apoptosis. Targeting by multivalent mannose significantly improved the capability of DOX‐loaded nanoparticles to inhibit the growth of MDA‐MB‐231 cancer cells with minimal side effects in vivo. This targeted and controlled drug delivery system holds promise as a nanotherapeutic for cancer treatment. |
| Keywords: | cancer chemotherapy mannose-mediated targeting multivalency nanoparticles targeted drug delivery |
