Easy To Synthesize,Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts |
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| Authors: | James P C Coverdale Dr Carlos Sanchez‐Cano Dr Guy J Clarkson Dr Rina Soni Prof?Dr Martin Wills Prof?Dr Peter J Sadler |
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| Affiliation: | Department of Chemistry, University of Warwick, Coventry, CV4 7AL (UK) |
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| Abstract: | Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori‐type RuII catalysts (arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X‐ray crystal structures of the 16‐electron OsII catalysts are almost identical to those of RuII. Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The OsII catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones. |
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| Keywords: | asymmetric catalysis hydrogen transfer ketone reduction organometallic complexes osmium |
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