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Accurate Extraction of Nanometer Distances in Multimers by Pulse EPR |
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| Authors: | Silvia Valera Dr Katrin Ackermann Dr Christos Pliotas Dr Hexian Huang Prof James H Naismith Dr Bela E Bode |
| Affiliation: | 1. Centre of Magnetic Resonance, University of St Andrews, St Andrews, UK;2. Biomedical Sciences Research Complex, University of St Andrews, St Andrews, UK;3. (+44)?1334 463808
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| Abstract: | Pulse electron paramagnetic resonance (EPR) is gaining increasing importance in structural biology. The PELDOR (pulsed electron–electron double resonance) method allows extracting distance information on the nanometer scale. Here, we demonstrate the efficient extraction of distances from multimeric systems such as membrane‐embedded ion channels where data analysis is commonly hindered by multi‐spin effects. |
| Keywords: | biomimetic synthesis deer EPR spectroscopy ion channels membrane proteins structural biology |
