Chiral Bis(imidazolidine)‐Derived NCN Pincer Rh Complex for Catalytic Asymmetric Mannich Reaction of Malononitrile with N‐Boc Imines |
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| Authors: | Prof?Dr Takayoshi Arai Takuma Moribatake Prof?Dr Hyuma Masu |
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| Affiliation: | 1. Molecular Chirality Research Center, Department of Chemistry, Graduate School of Science, Chiba University, 1‐33 Yayoi, Inage, Chiba 263‐8522 (Japan);2. Center for Analytical Instrumentation, Chiba University, 1‐33 Yayoi, Inage, Chiba 263‐8522 (Japan) |
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| Abstract: | Chiral bis(imidazolidine)‐derived NCN–rhodium complexes (PhBidine‐RhX2] and tBu‐PhBidine‐RhX2]) were prepared by a C?H insertion method, and the structures were unequivocally determined by X‐ray crystallographic analysis. The tBu‐PhBidine‐Rh(OAc)2] complex smoothly catalyzed an asymmetric Mannich reaction of malononitrile with N‐Boc imines to give products in up to 94 % ee, which are useful for the synthesis of chiral α‐amino acids. |
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| Keywords: | asymmetric catalysis malononitrile pincer complexes rhodium |
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