| 一种新型双吡啶悬臂Mn(Ⅱ)配合物的合成、晶体结构及DNA结合能力研究 |
| |
| 引用本文： | 王洋,李铭,吴宇,闫俊涛,毛佳伟.一种新型双吡啶悬臂Mn(Ⅱ)配合物的合成、晶体结构及DNA结合能力研究[J].人工晶体学报,2022,51(7):1220-1226. |
| |
| 作者姓名： | 王洋 李铭 吴宇 闫俊涛 毛佳伟 |
| |
| 作者单位： | 1.武汉轻工大学化学与环境工程学院,武汉 430023; 2.四川省产品质量监督检验检测院,成都 610100 |
| |
| 摘 要： | 通过3,3′-((乙烷-1,2-二基双(2-甲基吡啶杂氮二基)双(亚甲基))双(2-羟基-5-甲基苯甲醛)与2-羟基-1,3-丙二胺的缩合反应得到一种具有双吡啶悬臂的双核锰配合物。通过X射线单晶衍射确定了该配合物结构,结果显示其分子式为Mn2(C37H43N6O6)]·(ClO4)2。该配合物属于单斜晶系,P21/c空间群,晶胞参数为:a=1.096 50(19) nm, b=1.419 5(3) nm, c=3.109 4(5) nm, β=108.153(5)°。进一步分析表明两个二价锰离子分别与(Namine)2(Nimine)2O3和(Nimine)2O4体系配位,它们与配位原子形成的几何构型分别是十面体和扭曲的八面体。两个中心锰离子距离为0.331 6 nm,由酚氧原子和醋酸根共同桥联。另外,本文也利用伏安法和黏度法对该配合物与小牛胸腺DNA的结合能力进行研究,实验结果表明它们之间的结合方式为弱的插入作用。
|
| 关 键 词： | 双核锰配合物 大环金属配合物 晶体结构 DNA结合能力 |
| 收稿时间： | 2022-03-21 |
Synthesis,Crystal Structure,DNA Binding Ability of a New Bis-Pyridine Pendant-Arms Mn(Ⅱ) Complex |
| |
| WANG Yang,LI Ming,WU Yu,YAN Juntao,MAO Jiawei.Synthesis,Crystal Structure,DNA Binding Ability of a New Bis-Pyridine Pendant-Arms Mn(Ⅱ) Complex[J].Journal of Synthetic Crystals,2022,51(7):1220-1226. |
| |
| Authors: | WANG Yang LI Ming WU Yu YAN Juntao MAO Jiawei |
| |
| Affiliation: | 1. School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan 430023, China; 2. Sichuan Institute of Product Quality Supervision and Inspection, Chengdu 610100, China |
| |
| Abstract: | A new dinuclear manganese(Ⅱ) complex with bis-pyridine pendant-arms was synthesized by condensation between 3,3′-((ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl)) bis(methylene))bis(2-hydroxy-5-methylbenzaldehyde) and 2-hydroxy-1,3-diaminopropane in the presence of manganese(Ⅱ). The complex was determined by X-ray diffraction single crystal structure analysis, and the corresponding formula is Mn2(C37H43N6O6)]·(ClO4)2. The results indicate that the complex crystallizes in monoclinic, space group P21/c, with a=1.096 50(19) nm, b=1.419 5(3) nm, c=3.109 4(5) nm, β=108.153(5)°. The crystal structure shows that the two manganese(Ⅱ) ions in the phenolbased macrocyclic dinuclear complex are coordinated with (Namine)2(Nimine)2O3 and (Nimine)2O4 sites, the corresponding geometry around each manganese(Ⅱ) center are decahedron and distorted octahedron. Two manganese(Ⅱ) centers are equivalently bridged by the phenolic oxygens and an acetate radical with the intermetallic separation of 0.331 6 nm. Moreover, the binding ability of the complex toward calf thymus DNA were analyzed by voltammetric and viscosity method, which indicate the bonding mode between them is weak intercalation. |
| |
| Keywords: | dinuclear manganese(Ⅱ) complex macrocyclic metal complex crystal structure DNA binding ability |
|
| 点击此处可从《人工晶体学报》浏览原始摘要信息 |
|
点击此处可从《人工晶体学报》下载全文 |
|
