| 姜黄素对重离子辐射损伤小鼠睾丸组织的防护作用研究 |
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| 引用本文： | 赵邱越,王振华,谢漪,许帅,狄翠霞,张红.姜黄素对重离子辐射损伤小鼠睾丸组织的防护作用研究[J].原子核物理评论,2014,31(1):101-105. |
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| 作者姓名： | 赵邱越 王振华 谢漪 许帅 狄翠霞 张红 |
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| 作者单位： | 中国科学院近代物理研究所,兰州 730000; |
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| 基金项目： | 国家重点基础研究发展计划(973计划)项目(2010CB834202);国家自然科学基金项目(10835011);甘肃省重大科技专项项目(0702NKDA045,0806RJYA020);中国科学院西部之光人才培养计划项目(XB106012)~~ |
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| 摘 要： | 探讨姜黄素(Curcumin,简称Cur)对重离子辐射损伤小鼠睾丸组织的防护作用。小鼠灌胃不同剂量的Cur后给予4 Gy剂量~(12)C~(6+)离子束全身单次照射。24 h后对小鼠睾丸组织形态学变化进行观察,并测定丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性和过氧化氢酶(CAT)活性。结果显示:中、高浓度Cur预处理组对小鼠睾丸组织的形态具有较好的保护作用;低、中浓度Cur预处理组MDA含量显著降低(P0.05);与单纯照射组相比,低浓度Cur预处理组SOD活性水平和中浓度Cur预处理组CA了活性水平显著提高(P0.05)。结果表明:Cur对重离子全身辐射小鼠的抗氧化系统有一定的激活效应,对辐射损伤有一定的防护作用,其机制可能与Cur清除自由基,保护脂质和蛋白质有关。
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| 关 键 词： | 姜黄素 小鼠 12C6+离子 辐射防护 |
| 收稿时间： | 1900-01-01 |
Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams |
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| ZHAO Qiuyue,WANG Zhenhua,XIE Yi,XU Shuai,DI Cuixia,ZHANG Hong.Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams[J].Nuclear Physics Review,2014,31(1):101-105. |
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| Authors: | ZHAO Qiuyue WANG Zhenhua XIE Yi XU Shuai DI Cuixia ZHANG Hong |
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| Affiliation: | Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences,Lanzhou 730000, China;Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China; |
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| Abstract: | The protective effect of Curcumin (Cur) against the irradiation damage of testis in mice induced by 12C6+ ion beams was studied. Male Kung-Ming mice were exposed to whole body uniformly irradiated with 12C6+ ion beams at 4 Gy after pretreated with Cur of different concentration. Then histological alterations were observed. Moreover, malonaldehyde (MDA) level, superoxide dismutase (SOD) activity and catalase (CAT) activity were also measured at 24 h after irradiation. The result showed that middle and high dose Cur pretreated have a good protective effect. Compared with irradiated group, MDA level decreased dramatically in the group of pretreatment with low and middle dose Cur (P < 0:05). On the contrary, SOD activity in the pretreated group with low dose Cur significantly increased (P <0:05). Similarly, CAT activity in the pretreated group with middle dose Cur significantly increased (P <0:05). Data suggested that Cur could activate antioxidant system of testis in mice induced by12C6+ ion beams, it have some protective effect to radiation damage. The mechanism may involve in its scavenging reactive oxidant species and thenprotecting lipid and protein capability. |
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