Astrocyte and ions metabolism during epileptogenesis:A review for modeling studies |
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| Authors: | Meng-Meng Du Jia-Jia Li Zhi-Xuan Yuan Yong-Chen Fan Ying Wu |
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| Affiliation: | State Key Laboratory for Strength and Vibration of Mechanical Structures;School of Aerospace Engineering;National Demonstration Center for Experimental Mechanics Education |
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| Abstract: | As a large group of cells in a central nervous system, astrocytes have a great influence on ion and energy metabolism in a nervous system. Disorders of neuronal ion and energy metabolism caused by impaired astrocytes play a key role in the pathogenesis of epilepsy. This paper reviews the existing computational models of epileptogenesis resulting from impaired astrocytes and presents several open perspectives with regard to ion and energy metabolism-induced epileptogenesis in a neuron-astrocyte-capillary coupled model. |
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| Keywords: | epileptogenesis astrocyte potassium glutamate |
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