Migration and shape of cells on different interfaces |
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| Affiliation: | 1.Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China;2.School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;3.Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China;4.Songshan Lake Materials Laboratory, Dongguan 523808, China |
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| Abstract: | Impacts of microenvironments on cell migration have been reported in various interaction modes. A rapid tumor metastasis occurs along topological interfaces in vivo, such as the interface between the blood vessels and nerves. In this work, we culture MDA-MB231 cells at dish-liquid, dish-hydrogel, and hydrogel-liquid interfaces, respectively, to study how these different interfaces influence cell dynamics and morphology. Our results show that the migration mode of cells changes from an amoeboid motion to a mesenchymal motion but their speed do not change obviously if the interface changes from hydrogel-liquid to dish-liquid. In contrast, the migration mode of cells at a dish-hydrogel interface maintains as a mesenchymal motion, whereas their speed increases significantly. |
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| Keywords: | extracellular matrix cell migration cell morphology migration mode |
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