| 二维材料在生物传感器中的应用 |
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| 引用本文： | 罗实,魏大鹏,魏大程.二维材料在生物传感器中的应用[J].物理学报,2021(6):128-141. |
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| 作者姓名： | 罗实 魏大鹏 魏大程 |
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| 作者单位： | 复旦大学高分子科学系;复旦大学材料科学系;中国科学院重庆绿色智能技术研究院 |
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| 基金项目： | 中国科学院战略性先导科技专项(批准号:XDB30000000);国家自然科学基金(批准号:51773041,61890940,21603038);上海市自然科学基金(批准号:18ZR1404900);国家重点研发计划(批准号:2018YFA0703200)资助的课题。 |
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| 摘 要： | 自石墨烯发现以来,大量二维层状材料被相继发现.二维材料中载流子被限制在界面1 nm空间内,使其对化学掺杂非常敏感,有望引起生物传感领域的技术变革.生物传感过程无论基于何种传感机制,都包含了检测物识别和信号转化过程.检测物识别通常依靠传感界面的生物探针来完成,信号转换依靠二维材料来实现信号输出.在传感界面处对生物探针和二维材料进行原子级精准构筑,则可精确调控传感过程中的物理化学过程,优化器件的各项指标.本文综述了二维生物传感界面构筑领域的研究进展,重点介绍了目前几种常见的二维生物传感器的传感机制和不同类型的生物探针精准构筑方法,探讨了未来生物传感界面研究的发展方向.
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| 关 键 词： | 二维材料 生物传感 界面构筑 |
Applications of two-dimensional materials in bio-sensors |
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| Luo Shi,Wei Da-Peng,Wei Da-Cheng.Applications of two-dimensional materials in bio-sensors[J].Acta Physica Sinica,2021(6):128-141. |
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| Authors: | Luo Shi Wei Da-Peng Wei Da-Cheng |
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| Affiliation: | (State Key Laboratory of Molecular Engineering of Polymers,Department of Macromolecular Science,Fudan University,Shanghai 200433,China;Laboratory of Molecular Materials and Devices,Department of Materials Science,Fudan University,Shanghai 200433,China;Chongqing Key Laboratory of Multi-Scale Manufacturing Technology,Chongqing Institute of Green and Intelligent Technology,Chinese Academy of Sciences,Chongqing 400714,China) |
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| Abstract: | Since the discovery of graphene,a large number of two-dimensional(2D)materials have been found and studied.The charge carriers of 2D materials are restrained in a 1 nm physical space,which results in high sensitivity of charge carriers to chemical or electrical doping.It brings a technical innovation into a biosensing field.No matter what sensing mechanism the biosensor process is based on,it includes the process of detecting object recognition and signal transformation.The target recognition is normally realized by nano-bioprobes at the sensing interfaces of the devices.After the recognition,2D materials at the biosensing interface can realize signal output.Constructing bioprobes and 2D materials at an atomic level at the biosensing interface can modulate the physical and chemical activity precisely in the process of sensing,which improves the sensing performances of devices.Here,we review the recent progress of constructing the 2D biosensing interfaces.Especially,we discuss various biosensing mechanisms and different nano-bioprobes.We also suggest the further research direction of this field. |
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| Keywords: | two-dimensional materials biosensing interface fabrication |
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