Ruthenium‐Catalyzed Tandem‐Isomerization/Asymmetric Transfer Hydrogenation of Allylic Alcohols |
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| Authors: | Tove Slagbrand Helena Lundberg Prof. Dr. Hans Adolfsson |
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| Affiliation: | Dept. of Organic Chemistry, Stockholm University, The Arrhenius Laboratory, 10691 Stockholm (Sweden) |
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| Abstract: | ![]()
A one‐pot procedure for the direct conversion of racemic allylic alcohols to enantiomerically enriched saturated alcohols is presented. The tandem‐isomerization/asymmetric transfer hydrogenation process is efficiently catalyzed by [{Ru(p‐cymene)Cl2}2] in combination with the α‐amino acid hydroxyamide ligand 1 , and performed under mild conditions in a mixture of ethanol and THF. The saturated alcohol products are isolated in good to excellent chemical yields and in enantiomeric excess up to 93 %. |
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| Keywords: | allylic alcohols asymmetric catalysis isomerization reduction ruthenium |
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