Asymmetric Reduction of α‐Amino Ketones with a KBH4 Solution Catalyzed by Chiral Lewis Acids |
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| Authors: | Peng He Haifeng Zheng Prof Dr Xiaohua Liu Xiangjin Lian Dr Lili Lin Prof Dr Xiaoming Feng |
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| Affiliation: | Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (P. R. China), Fax: (+86)?28‐8541‐8249 |
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| Abstract: | An efficient enantioselective reduction of α‐amino ketones with potassium borohydride solution catalyzed by chiral N,N′‐dioxide–metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approaches for obtaining synthetically important chiral β‐amino alcohols in good to excellent yields (up to 98 %) and enantioselectivities (up to 97 % ee). |
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| Keywords: | alcohols asymmetric synthesis N N′ ‐dioxide– metal complex ketones reduction |
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