Design,synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes with a tetradentate carrier ligand |
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| Authors: | Chuan‐Zhu Gao Tian‐Shuai Wang Yan Zhang Ji Chen Yun‐Xu Qian Bo Yang Ying‐Jie Zhang |
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| Affiliation: | 1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China;2. Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, China |
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| Abstract: | Four novel dinuclear platinum complexes with a tetradentate ligand, (1R,1′R,2R,2′R)‐N1,N1′‐(1,2‐phenylenebis(methylene))dicyclohexane‐1,2‐diamine, as the carrier group, have been designed, synthesized and characterized, and their in vitro cytotoxicity against HepG‐2, A549, HCT‐116 and MCF‐7 cell lines evaluated using MTT assay. Results indicate that the targeted dinuclear platinum complexes H1 , H2 , H3 , H4 exhibit significant growth inhibitory properties against HepG‐2, A549 and HCT‐116 cell lines, but none of them show activity against MCF‐7 cell line. Compound H4 shows better antitumor activity than carboplatin against HepG‐2, A549 and HCT‐116 cell lines. Copyright © 2015 John Wiley & Sons, Ltd. |
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| Keywords: | dinuclear platinum complexes tetradentate ligand in vitro cytotoxicity |
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