Synthesis and properties of m‐ferrocenylbenzoylthiadiazole derivatives |
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| Authors: | Biao Li Xinju Zhu Yuan Guo Ya‐Ping Ren Zhao‐Dong Jia Jing‐Na Wei Dong‐Xia Fu Yan Xu Xin‐Qi Hao |
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| Affiliation: | College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan, People's Republic of China |
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| Abstract: | A series of m‐ferrocenylbenzoylthiadiazole compounds, namely FcL1–FcL7, were synthesized using 3‐ferrocenylbenzoic acid and 2‐amino‐5‐aryl‐1,3,4‐thiadiazole as raw materials. These compounds were characterized using infrared and NMR spectroscopies and elemental analysis. The crystal structure of FcL7 was determined using X‐ray diffraction. The electrochemical behaviors of FcL1–FcL7 revealed that the redox reactions on the surface of electrodes were reversible with a single‐electron mechanism. Also, FcL1–FcL7 demonstrated certain redox responses to Pb2+ and Zn2+. Moreover, FcL5–FcL7 exhibited good inhibition against human esophageal cancer cells in anticancer activity tests. |
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| Keywords: | biological activity crystal structure electrochemistry ferrocene thiadiazole |
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