Palladium‐Catalyzed Cross‐Coupling of Styrenes with Aryl Methyl Ketones in Ionic Liquids: Direct Access to Cyclopropanes |
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| Authors: | Dr Pietro Cotugno Dr Antonio Monopoli Prof Francesco Ciminale Dr Antonella Milella Prof Angelo Nacci |
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| Affiliation: | 1. Department of Chemistry, University of Bari, Via Orabona 4, 70126 Bari (Italy);2. CNR‐ICCOM, Department of Chemistry, University of Bari, Via Orabona 4, 70126 Bari (Italy) |
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| Abstract: | The combined use of Pd(OAc)2, Cu(OAc)2, and dioxygen in molten tetrabutylammonium acetate (TBAA) promotes an unusual cyclopropanation reaction between aryl methyl ketones and styrenes. The process is a dehydrogenative cyclizing coupling that involves a twofold C? H activation at the α‐position of the ketone. The substrate scope highlights the flexibility of the catalyst; a reaction mechanism is also proposed. |
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| Keywords: | C H activation copper cyclopropanation ionic liquids palladium |
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