Chiral Palladacycle Catalysts Generated on a Single‐Handed Helical Polymer Skeleton for Asymmetric Arylative Ring Opening of 1,4‐Epoxy‐1,4‐dihydronaphthalene |
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| Authors: | Dr Takeshi Yamamoto Yuto Akai Prof?Dr Michinori Suginome |
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| Affiliation: | 1. Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo‐ku, Kyoto 615‐8510 (Japan);2. JST, CREST, Katsura, Nishikyo‐ku, Kyoto 615‐8510 (Japan) |
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| Abstract: | Post‐polymerization C? H activation of poly(quinoxaline‐2,3‐diyl)‐based helically chiral phosphine ligands (PQXphos) with palladium(II) acetate afforded chiral phosphapalladacycles quantitatively. In situ generated palladacycles exhibited enantioselectivities up to 94 % ee in the palladium‐catalyzed asymmetric ring‐opening arylation of 1,4‐epoxy‐1,4‐dihydronaphthalenes with arylboronic acids. |
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| Keywords: | asymmetric synthesis helical structures ligand design palladacycles polymer catalyst |
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