Cooperative Catalysis by Palladium and a Chiral Phosphoric Acid: Enantioselective Amination of Racemic Allylic Alcohols |
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| Authors: | Dr. Debasis Banerjee Dr. Kathrin Junge Prof. Dr. Matthias Beller |
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| Affiliation: | Leibniz‐Institut für Katalyse an der Universit?t Rostock, Albert‐Einstein‐Strasse 29a, 18059 Rostock (Germany) http://www.catalysis.de |
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| Abstract: | ![]()
Cooperative catalysis by [Pd(dba)2] and the chiral phosphoric acid BA1 in combination with the phosphoramidite ligand L8 enabled the efficient enantioselective amination of racemic allylic alcohols with a variety of functionalized amines. This catalytic protocol is highly regio‐ and stereoselective (up to e.r. 96:4) and furnishes valuable chiral amines in almost quantitative yield. |
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| Keywords: | allylic alcohols asymmetric amination chiral phosphoric acids palladium phosphoramidite ligands |
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