A Visible‐Light‐Driven Iminyl Radical‐Mediated C−C Single Bond Cleavage/Radical Addition Cascade of Oxime Esters |
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| Authors: | Xiao‐Ye Yu Prof?Dr Jia‐Rong Chen Peng‐Zi Wang Meng‐Nan Yang Dong Liang Prof?Dr Wen‐Jing Xiao |
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| Affiliation: | 1. CCNU-uOttawa Joint Research Centre, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei, China;2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China |
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| Abstract: | A room‐temperature, visible‐light‐driven N‐centered iminyl radical‐mediated and redox‐neutral C?C single bond cleavage/radical addition cascade reaction of oxime esters and unsaturated systems has been accomplished. The strategy tolerates a wide range of O‐acyl oximes and unsaturated systems, such as alkenes, silyl enol ethers, alkynes, and isonitrile, enabling highly selective formation of various chemical bonds. This method thus provides an efficient approach to various diversely substituted cyano‐containing alkenes, ketones, carbocycles, and heterocycles. |
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| Keywords: | heterocycles iminyl radicals N-centered radicals nitriles photoredox catalysis |
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