A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals |
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| Authors: | Dr Wei Chen Armando Pacheco Yoko Takano Jacob J Day Prof?Dr Kenjiro Hanaoka Prof?Dr Ming Xian |
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| Affiliation: | 1. Department of Chemistry, Washington State University, Pullman, WA, USA;2. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan |
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| Abstract: | Hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn, n>1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross‐talk between H2S and H2Sn, it is highly desirable to develop single fluorescent probes which enable dual‐channel discrimination between H2S and H2Sn. Herein, we report the rational design, synthesis, and evaluation of the first dual‐detection fluorescent probe DDP‐1 that can visualize H2S and H2Sn with different fluorescence signals. The probe showed high selectivity and sensitivity to H2S and H2Sn in aqueous media and in cells. |
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| Keywords: | cyclization fluorescence fluorescent probes hydrogen polysulfides sulfides |
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