Heterogeneously Porous γ‐MnO2‐Catalyzed Direct Oxidative Amination of Benzoxazole through CH Activation in the Presence of O2 |
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| Authors: | Provas Pal Arnab Kanti Giri Harshvardhan Singh Dr Subhash Chandra Ghosh Dr Asit Baran Panda |
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| Affiliation: | Discipline of Inorganic Materials and Catalysis, & Academy of Scientific and Innovative Research, Central Salt and Marine Chemicals Research Institute (CSIR), G.B. Marg, Bhavnagar‐364002, Gujarat (India), Fax: (+91)?278‐2567562 |
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| Abstract: | Oxidative amination of azoles through catalytic C? H bond activation is a very important reaction due to the presence of 2‐aminoazoles in several biologically active compounds. However, most of the reported methods are performed under homogeneous reaction conditions using excess reagents and additives. Herein, we report the heterogeneous, porous γ‐MnO2‐catalyzed direct amination of benzoxazole with wide range of primary and secondary amines. The amination was carried under mild reaction conditions and using molecular oxygen as a green oxidant, without any additives. The catalyst can easily be separated by filtration and reused several times without a significant loss of its catalytic performance. Of note, the reaction tolerates a functional group such as alcohol, thus indicating the broad applicability of this reaction. |
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| Keywords: | amination benzoxazole C H activation heterogeneous catalysis manganese |
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