Ring Opening Metathesis Polymerization of Bicyclic α,β‐Unsaturated Anhydrides for Ready‐to‐be‐grafted Polymers Having Tailored pH‐Responsive Degradability |
| |
| Authors: | Heejin Kim Sungwhan Kim Sunyoung Kang Youngjun Song Dr Suyong Shin Dr Seonju Lee Minji Kang Dr So Hee Nam Prof?Dr Yan Lee |
| |
| Affiliation: | Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea |
| |
| Abstract: | Polymers having α,β‐unsaturated anhydrides as repeating units were synthesized by ring opening metathesis polymerization (ROMP). The anhydride moieties were ready‐to‐be‐grafted with amines to form acid‐labile cis‐α,β‐unsaturated acid amide linkages. The pH‐responsive reversible de‐grafting can be controlled by changing the intramolecular accessibility between acid and amide groups. The alendronate‐grafted ROMP polymers showed distinct pH‐dependent cytotoxicity according to the anhydride structures. |
| |
| Keywords: | α β -unsaturated amides bicyclic anhydrides pH degradability reversible grafting and release ROMP |
|
