Water Mediated Domino Knoevenagel‐Michael‐cyclocondensation Reaction of Malononitrile,Various Aldehydes and Barbituric Acid Derivatives Using Boric Acid Aqueous Solution System Compared with Nano‐titania Sulfuric Acid |
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| Authors: | Ardeshir Khazaei Heidar Ali Alavi Nik Ahmad Reza Moosavi‐Zare |
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| Affiliation: | 1. Faculty of Chemistry, Bu‐Ali Sina University, Hamedan, 6517838683, Iran;2. Department of Chemistry, University of Sayyed Jamaleddin Asadabadi, Asadabad, 6541835583, Iran |
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| Abstract: | Nano‐titania sulfuric acid (TSA) and boric acid [B(OH)3] were efficiently utilized for domino Knoevenagel‐Michael‐cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives to synthesis of pyrano[2,3‐d]pyrimidine diones. It is interesting that in boric acid aqueous solution system, H+ which abstracted from water by the interaction with B(OH)3, efficiently catalyzed the reaction. |
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| Keywords: | Pyrano[2,3‐d]pyrimidine dione Nano‐titania sulfuric acid Boric acid Barbituric acid Malononitrile Aldehyde |
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