A Glutathione‐Activated Phthalocyanine‐Based Photosensitizer for Photodynamic Therapy |
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| Authors: | Dr Hui He Prof Pui‐Chi Lo Prof Dennis K P Ng |
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| Affiliation: | Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (P. R. China), Fax: (+852)?2603 5057 |
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| Abstract: | A zinc(II) phthalocyanine substituted with a 2,4‐dinitrobenzenesulfonate group has been prepared. Its fluorescence emission and reactive oxygen species generation can be greatly enhanced by glutathione in phosphate‐buffered saline and inside MCF‐7 cells. This compound thus functions as a highly efficient molecular‐based activatable photosensitizer. |
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| Keywords: | glutathione photodynamic therapy photosensitizers phthalocyanines singlet oxygen |
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