Synthesis and Cytotoxic Activity of 1‐{3‐[1‐(5‐Organylsilylfuran‐2‐yl)silinan‐1‐yl]propyl}amines and Some Trimethylgermyl Analogues |
| |
| Authors: | Dr Luba Ignatovich Dr Vitalijs Romanovs Velta Muravenko Ilze Sleiksha Dr Jury Popelis Dr Irina Shestakova |
| |
| Affiliation: | Laboratory of Organometallic Chemistry, Laboratory of Physico‐Organic Chemistry, Experimental chemotherapy group Latvian Institute of Organic Synthesis, Aizkraukles 21, LV1006 Riga (Latvia), Fax: (+371)?67014948 |
| |
| Abstract: | New highly cytotoxic 1‐{3‐1‐(5‐organylsilyl‐furan‐2‐yl)silinan‐1‐yl]propyl}amines and some trimethylgermyl analogues (IC50 1–7 μg mL?1) have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N‐allylamines in the presence of Speier’s catalyst. The effects of the silacycle, the element‐organic substituent in position 5 of the furan ring, and the structure of the amine on the cytotoxicity of the new compounds have been studied. |
| |
| Keywords: | cytotoxicity furylsilinanes silicon chemistry 29Si NMR spectroscopy toxicity |
|
