Nickel‐Catalyzed Site‐Selective Amidation of Unactivated C(sp3)H Bonds |
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| Authors: | Dr Xuesong Wu Yan Zhao Prof Dr Haibo Ge |
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| Affiliation: | 1. Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202 (USA), Fax: (+1)?317‐2744701;2. Institute of Chemistry and BioMedical Sciences and School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P. R. China) |
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| Abstract: | Intramolecular dehydrogenative cyclization of aliphatic amides was achieved on unactivated sp3 carbon atoms by a nickel‐catalyzed C?H bond functionalization process with the assistance of a bidentate directing group. The reaction favors the C?H bonds of β‐methyl groups over the γ‐methyl or β‐methylene groups. Additionally, a predominant preference for the β‐methyl C?H bonds over the aromatic sp2 C?H bonds was observed. Moreover, this process also allows for the effective functionalization of benzylic secondary sp3 C?H bonds. |
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| Keywords: | amidation C H bond functionalization nickel site selectivity β ‐lactams |
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