Terpenoids from the Stems of Drypetes congestiflora |
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| Authors: | Wen‐Hao Chen Chang‐Ri Han Yang Hui Da‐Shuai Zhang Xin‐Ming Song Guang‐Ying Chen Xiao‐Ping Song |
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| Affiliation: | Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainnan Normal University, Haikou, 571158, P.?R. China, (phone/fax: +86‐898‐65889422) |
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| Abstract: | Two new eremophilane‐type sesquiterpenoids, 1α‐hydroxyeremophila‐6,9,11‐trien‐8‐one ( 1 ), 4α‐hydroxyeremophila‐1,9‐diene‐3,8‐dione ( 2 ), and a new friedelane‐type triterpenoid, friedelane‐3α,16β‐diol ( 4 ), along with six known terpenoids, 3 and 5 – 9 , have been isolated from the stems of Drypetes congestiflora. Their structures and relative configurations were elucidated on the basis of detailed spectroscopic analyses and by comparison of their NMR data with those reported in the literature. All of the compounds, 1 – 9 , were isolated for the first time from this species. Compound 3 exhibited moderate cytotoxic activities against the A549 and B16F10 cell lines. |
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| Keywords: | Drypetes congestiflora Sesquiterpenoids Terpenoids Cytotoxic activity |
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