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Non‐Aqueous Sol–Gel Synthesis of Ultra Small Persistent Luminescence Nanoparticles for Near‐Infrared In Vivo Imaging |
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| Authors: | Dr Thomas Maldiney Nicole Lièvre Dr Guillaume Yangshu Wang Prof Laurence Motte Dr Cyrille Richard Dr Yoann Lalatonne |
| Affiliation: | 1. Unité de Technologies Chimiques et Biologiques pour la Santé, CNRS, UMR 8258, Paris, 75270 cedex (France), Inserm, U1022, Paris, 75270 cedex (France), Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, 75270 cedex (France), ENSCP, Paris, 75231 cedex France, Chimie Paristech (France);2. Université Paris 13, Sorbonne Paris Cité, UPRES 3410 Biothérapies Bénéfices et Risques, 74 avenue M. Cachin 93017 Bobigny (France);3. Laboratoire Matériaux et Phénomènes Quantiques, UMR 7162 CNRS/Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris Cedex 13 (France);4. Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS, UMR 7244, 74avenue M. Cachin 93017 Bobigny (France), Service de Médecine Nucléaire, H?pital Avicenne, 125 rue de Stalingrad, 93009 Bobigny (France) |
| Abstract: | Ultra‐small ZnGa2O4:Cr3+ nanoparticles (6 nm) that exhibit near‐infrared (NIR) persistent luminescence properties are synthesized by using a non‐aqueous sol–gel method assisted by microwave irradiation. The nanoparticles are pegylated, leading to highly stable dispersions under physiological conditions. Preliminary in vivo studies show the high potential for these ultra‐small ZnGa2O4:Cr3+ nanoparticles to be used as in vivo optical nanotools as they emit without the need for in situ excitation and, thus, avoid the autofluorescence of tissues. |
| Keywords: | infrared in vivo imaging luminescence nanoparticles oxides |
