Rhodium‐catalyzed Asymmetric Hydrogenation of α‐Dehydroamino Ketones: A General Approach to Chiral α‐amino Ketones |
| |
| Authors: | Wenchao Gao Qingli Wang Yun Xie Dr. Hui Lv Prof. Dr. Xumu Zhang |
| |
| Affiliation: | Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, China |
| |
| Abstract: | Rhodium/DuanPhos‐catalyzed asymmetric hydrogenation of aliphatic α‐dehydroamino ketones has been achieved and afforded chiral α‐amino ketones in high yields and excellent enantioselectives (up to 99 % ee), which could be reduced further to chiral β‐amino alcohols by LiAlH(tBuO)3 with good yields. This protocol provides a readily accessible route for the synthesis of chiral α‐amino ketones and chiral β‐amino alcohols. |
| |
| Keywords: | asymmetric catalysis hydrogenation P ligands rhodium α -amino ketones |
|
